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Key points Graves disease is an autoimmune condition that can involve the thyroid exclusively or can be associated with extrathyroidal manifestations, of which Graves orbitopathy is the most common

Stimulates collagen production helping improve skin elasticity and firmness

Inhibition of syndecan-4 reduces cartilage degradation in murine models of osteoarthritis through the downregulation of HIF-2by miR-96-5p

Synergistic action of microbiota modulation and metabolic surgery The significant improvement of NAFLD by metabolic surgery (such as sleeve gastrectomy) is partly attributed to its remodeling of the gut microbiota, providing a theoretical basis for combined microbial intervention in the perioperative period